MARS
MARS - Molecular Diagnosis and Risk Stratification of Sepsis...
Description
MARS is a multicenter prospective cohort of ICU patients aimed at developing new molecular technologies for early diagnosis and risk stratification of sepsis....
General Design
- Cohort type
Clinical cohort, Biobank
- Design
Longitudinal
- Design description
Ongoing prospective cohort and biobank of ICU patients admitted to the UMC Utrecht since 2011. The AMC was a participating center between 2011 and 2013.
- Collection type
Prospective
- Start/End year
2011 - ongoing
Population
- Countries
Netherlands (the)
- Regions
Noord-Holland, Utrecht
- Number of participants
17000
- Number of participants with samples
16000
- Population age groups
Adult (18+ years)
- Main medical condition
- I Certain infectious and parasitic diseases
- A30-A49 Other bacterial diseases
- A41.9 Sepsis, unspecified
- Inclusion criteria
- Age group inclusion criterion
- Defined population inclusion criterion
- Health status inclusion criterion
- Hospital patient inclusion criterion
- Other inclusion criteria
ICU admitted patients, with exception of elective cardiothoracic surgery patients.
Contributors
Additional organisations
- Amsterdam Medical Center
Available Data & Samples
Data categories
- Biological samples
Sample categories
- Plasma
- RNA
- Blood
- Blood Buffy Coat
- DNA
Subpopulations
List of subcohorts or subpopulations for this resource...
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Collection events
List of collection events defined for this resource...
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Datasets
List of datasets for this resource...
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Partners
Networks
List of networks in which this cohort is involved...
Publications
Electronic Implementation of a Novel Surveillance Paradigm for Ventilator-associated Events. Feasibility and Validation
Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis
Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study
Validation of a Novel Molecular Host Response Assay to Diagnose Infection in Hospitalized Patients Admitted to the ICU With Acute Respiratory Failure
Access conditions
Data and samples are accessible after permission of the principal investigator of the MARS cohort. In general, ethics approval is required for use of biobank samples (TCBio approval)....
- Data access conditions
- health or medical or biomedical research
- disease specific research
- Data use conditions
- research specific restrictions
- collaboration required
- ethics approval required
- project specific restriction
- Data access fee
true
- Release type
- Closed dataset
- Linkage options
The questionnaires sent out at 1 year after ICU discharge can be linked to the MARS database. These questionnaires contain data on quality of life and mental well-being at 1 year. Upon request, the MARS database can be enriched with additional healthcare data from the EPD.
Funding & Acknowledgements
- Funding
The MARS cohort received a grant from the Center for Translational Molecular Medicine (http://www.ctmm.nl) project MARS (grant 04I-201).